Table 4.
Logistic regression models with onset of major depressive disorder at 6 or 12 months of follow-up as dependent variable, and the life event groups, age in 10 year groups and their interaction as independent variables, stratified by sex.
| Onset of MDD at follow-up (N = 6910) |
|||
|---|---|---|---|
| RERIadjusted (95% CI) | |||
| Total | Women | Men | |
| No life events and 18 to 29 years of age | (Reference) | (Reference) | (Reference) |
| One life event and 30 to 39 years of age | 0.90 (0.08 to 1.72)⁎ | 1.05 (0.22 to 1.87)⁎ | − 2.83 (− 12.38 to 6.72) |
| One life event and 40 to 49 years of age | 0.89 (0.05 to 1.73)⁎ | 0.82 (0.02 to 1.62)⁎ | 0.34 (− 8.34 to 9.03) |
| One life event and 50 to 59 years of age | 0.33 (− 0.67 to 1.32) | 0.39 (− 0.56 to 1.34) | − 0.75 (− 9.11 to 7.61) |
| One life event and 60 to 69 years of age | 0.48 (− 0.40 to 1.36) | 0.32 (− 0.58 to 1.21) | 1.39 (− 4.74 to 7.52) |
| One life event and 70 to 75 years of age | − 0.10 (− 1.13 to 0.93) | 0.26 (− 0.73 to 1.24) | − 3.60 (− 14.10 to 6.89) |
| No life events and 18 to 29 years of age | (Reference) | (Reference) | (Reference) |
| Two or more life events and 30 to 39 years of age | 0.71 (− 0.20 to 1.62) | 0.74 (− 0.16 to 1.63) | − 0.42 (− 14.33 to 13.49) |
| Two or more life events and 40 to 49 years of age | 2.63 (1.22 to 4.03)⁎ | 2.29 (1.02 to 3.55)⁎ | 10.14 (− 12.02 to 32.30) |
| Two or more life events and 50 to 59 years of age | 0.13 (− 0.81 to 1.06) | 0.33 (− 0.58 to 1.26) | − 2.08 (− 10.48 to 6.33) |
| Two or more life events and 60 to 69 years of age | 0.55 (− 0.63 to 1.72) | 0.67 (− 0.20 to 1.54) | 0.39 (− 7.20 to 6.42) |
| Two or more life events and 70 to 75 years of age | 0.53 (− 0.68 to 1.74) | 0.40 (− 0.80 to 1.60) | 2.03 (− 6.97 to 11.03) |
| No personal problems and 18 to 29 years of age | (Reference) | (Reference) | (Reference) |
| Personal problems and 30 to 39 years of age | 0.10 (− 1.28 to 1.49) | 0.25 (− 1.13 to 1.62) | − 0.34 (− 6.67 to 5.99) |
| Personal problems and 40 to 49 years of age | 2.23 (0.33 to 4.13)⁎ | 2.66 (0.55 to 4.76)⁎ | − 1.78 (− 9.83 to 6.28) |
| Personal problems and 50 to 59 years of age | 0.86 (− 0.47 to 2.20) | 0.61 (− 0.75 to 1.99) | 1.86 (− 4.33 to 8.05) |
| Personal problems and 60 to 69 years of age | 0.78 (− 0.45 to 2.04) | 0.82 (− 0.52 to 2.15) | 0.31 (− 5.07 to 5.68) |
| Personal problems and 70 to 75 years of age | − 0.63 (− 1.98 to 0.72) | − 0.48 (− 1.82 to 0.85) | − 1.99 (− 7.88 to 3.90) |
| No relational problems and 18 to 29 years of age | (Reference) | (Reference) | (Reference) |
| Relational problems and 30 to 39 years of age | 0.39 (− 0.35 to 1.13) | 0.44 (− 0.32 to 1.21) | − 0.10 (− 2.78 to 2.57) |
| Relational problems and 40 to 49 years of age | 1.12 (0.23 to 2.01)⁎ | 1.00 (0.16 to 1.85)⁎ | 2.17 (− 2.76 to 7.08) |
| Relational problems and 50 to 59 years of age | − 0.29 (− 1.16 to 0.58) | − 0.09 (− 0.97 to 0.79) | − 0.89 (− 4.23 to 2.45) |
| Relational problems and 60 to 69 years of age | − 0.03 (− 0.83 to 0.76) | − 0.02 (− 0.83 to 0.78) | − 0.01 (− 3.09 to 3.07) |
| Relational problems and 70 to 75 years of age | − 0.03 (− 0.94 to 0.87) | − 0.08 (− 1.05 to 0.89) | 0.20 (− 2.54 to 2.95) |
| No work/financial problems and 18 to 29 years of age | (Reference) | (Reference) | (Reference) |
| Work/financial problems and 30 to 39 years of age | 0.41 (− 0.96 to 1.78) | 0.40 (− 1.07 to 1.86) | 0.16 (− 3.78 to 4.11) |
| Work/financial problems and 40 to 49 years of age | 1.85 (0.07 to 3.63)⁎ | 1.47 (− 0.24 to 3.18) | 4.82 (− 4.70 to 14.35) |
| Work/financial problems and 50 to 59 years of age | 0.20 (− 1.19 to 1.60) | 0.45 (− 1.20 to 2.09) | 0.75 (− 3.50 to 4.99) |
| Work/financial problems and 60 to 69 years of age | 0.57 (− 0.99 to 2.14) | 1.21 (− 0.63 to 3.05) | − 3.42 (− 8.14 to 1.29) |
| Work/financial problems and 70 to 75 years of age | 1.36 (− 1.62 to 4.35) | 1.39 (− 2.30 to 5.07) | 1.98 (− 4.67 to 8.64) |
| No events in family/friends and 18 to 29 years of age | (Reference) | (Reference) | (Reference) |
| Events in family/friends and 30 to 39 years of age | 0.39 (− 0.63 to 1.41) | 0.46 (− 0.56 to 1.49) | − 1.33 to (− 7.87 to 5.21) |
| Events in family/friends and 40 to 49 years of age | 2.66 (1.08 to 4.23)⁎ | 2.59 (1.03 to 4.15)⁎ | 2.29 (− 5.43 to 10.00) |
| Events in family/friends and 50 to 59 years of age | 0.40 (− 0.64 to 1.44) | 0.95 (− 0.25 to 2.16) | − 1.90 (− 7.76 to 3.95) |
| Events in family/friends and 60 to 69 years of age | 0.30 (− 0.90 to 1.50) | 0.38 (− 0.83 to 1.59) | − 0.35 (− 6.11 to 5.41) |
| Events in family/friends and 70 to 75 years of age | 1.51 (− 0.92 to 3.93) | 1.52 (− 1.10 to 4.15) | 1.05 (− 7.25 to 9.35) |
| No problems with law and 18 to 29 years of age | (Reference) | (Reference) | (Reference) |
| Problems with law and 30 to 39 years of age | 0.20 (− 1.12 to 1.52) | 0.33 (− 0.98 to 1.64) | − 1.24 (− 6.62 to 4.13) |
| Problems with law and 40 to 49 years of age | 3.87 (1.21 to 6.53)⁎ | 3.33 (0.76 to 5.91)⁎ | 8.52 (− 5.56 to 22.60) |
| Problems with law and 50 to 59 years of age | − 0.08 (− 1.21 to 1.05) | 0.15 (− 1.14 to 1.45) | − 1.64 (− 7.14 to 3.87) |
| Problems with law and 60 to 69 years of age | 1.12 (− 0.34 to 2.58) | 1.67 (− 0.08 to 3.41) | − 1.55 (− 6.68 to 3.57) |
| Problems with law and 70 to 75 years of age | 1.07 (− 1.00 to 3.14) | 1.34 (− 1.04 to 3.71) | − 0.06 (− 5.92 to 5.80) |
MDD = major depressive disorder, CI = confidence interval, RERI = relative excess risk due to interaction.
RERI formula = ORA+B + − ORA + B − − ORA−B + + 1.
All models are adjusted for level of education and country.
⁎
Significant departure from additivity; note that in the absence of interaction as departure from additivity, RERI = 0.