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. 2012 Mar;62(4):1695–1699. doi: 10.1016/j.neuropharm.2011.11.015

Fig. 1.

Fig. 1

Selective potentiation of DHPG responses by Ro67-4853. A–C: Records are counts of action potentials (in 1 s epochs) recorded from a single neurone in response to application of either DHPG or NMDA, as indicated by the marker bars above the records. A – Control responses. B – Responses during the co-application of Ro67-4853 (that had commenced 150 s previously). C – Recovery (washout) from the Ro67-4853 effect. Record commenced 150 s after the end of the PAM application. D & E: Overall effect of Ro67-4853 or Vehicle on agonist responses. Bars represent mean % change from control (100%) of responses to either NMDA or DHPG during application of the PAM or Vehicle, and recovery of agonist responses after termination of the PAM or Vehicle application. D – Ro67-4853 produced a significant selective potentiation of DHPG responses, with little effect on NMDA responses. Data from 15 neurones. E – Passing iontophoretic current through Vehicle-containing barrel had no significant effect on responses to either NMDA or DHPG. Data from 5 neurones that were also tested with Ro67-4853 and included in A. ***P < 0.001; ns not significant.