Fig. 3.

Overall effect of Ro67-4853 on responses to single stimuli or trains of stimuli directed at vibrissae. Bars represent mean % change from control (100%) of responses to vibrissa stimulation during application of the PAM and recovery of responses after termination of the PAM application. A – Responses of 18 neurones to single stimuli were not affected by the PAM. B – Responses of 20 neurones to trains of vibrissa stimulation were potentiated by PAM application. When responses were segregated into the initial response component (to the first stimulus in the train) and the remaining maintained response component, it was the latter that was potentiated by the PAM. C – Responses of 8 of the neurones shown in B showing the effect of PAM application on maintained sensory responses under control conditions, and during co-application of the mGlu1 antagonist LY367385 (box). Note that LY367385 prevented the potentiation of responses by the PAM. ***P < 0.001; **P < 0.01; *P < 0.05; ns not significant.