Figure 4.

Axonal Injury Results in Extensive Neuron Death in c-Jun Mutants

(A and B) Number of unmyelinated axons in L4 dorsal roots (A) and number of small neuronal cell body profiles (B cells) in corresponding DRGs (B), expressed relative to number of B cells in uninjured WT mice. The data show before (0) and at different times after injury. Error bars: ± SEM; ^∗p < 0.05, n = 4).

(C and D) Number of myelinated axons in L4 dorsal roots (C) and large neuronal cell body profiles (A cells) in corresponding DRGs (D), expressed relative to the number of A cells in uninjured WT mice. The data show before (0) and at different times after injury. Error bars: ± SEM; ^∗p < 0.05, n = 4.

(E and F) Number of myelinated (E) and unmyelinated (F) axons in tibial nerves (midthigh level) before injury and 10 weeks postcrush in WT and mutant mice. Error bars: ± SEM; ^∗p < 0.05, n = 4. Note that axon and neuron numbers are normal in c-Jun mutants before injury, but significantly reduced post nerve crush.

See also Figure S2.