Table 1.
OGTT-derived indexes of insulin sensitivity, metabolic clearance rates, and first and second phase insulin release based on Strumvoll et al [17]in EARSII.
| rs2943641 genotype | Insulin sensitivity index | p-valuea | Metabolic clearance rate | p-valuea | First phase insulin release | p-valuea | Second phase insulin release | p-valuea |
|---|---|---|---|---|---|---|---|---|
| CC | 0.118 (0.001) | 9.96 (0.072) | 1225.2 (24.3) | 324.3 (5.3) | ||||
| CT | 0.121 (0.001) | 0.008 | 10.21 (0.071) | 0.008 | 1197.8 (23.4) | 0.83 | 317.7 (10.4) | 0.72 |
| TT | 0.122 (0.002) | 10.29 (0.139) | 1235.7 (47.3) | 325.0 (10.4) |
Abbreviations: OGTT = oral glucose tolerance test; EARSII = European Atherosclerosis Research Study-II.
Results are mean ± SEM.
a
P-values adjusted for age, ‘case’/‘control’ status and region.