Table 3. Significant neuronal function-related GO annotations and associated genes and lineages.
| Annotation | Gene | Human | Chimpanzee | Human–chimpanzee | Gorilla | African ape–macaque* |
|---|---|---|---|---|---|---|
| Axon guidance | NRXN3 | U (19–21) | ||||
| Dendrite morphogencsis | PTD009 | U (12–15) | ||||
| GABAA receptor activity | GABRB3 | U (12–20) | D (22–20) | |||
| GABA/sodium symporter activity | SLC6A1 | D (22–20) | ||||
| GABA acid transporter activity | SLC6A1 | D (22–20) | ||||
| Glia cell migration | SLIT2 | U (12–14) | ||||
| Motor axon guidance | SLIT2 | U (12–14) | ||||
| Neuromuscular junction development | CUGBP2 | D (24–22) | ||||
| Neuromuscular synaptic transmission | DTNA | D (20–17) | ||||
| Neuron differentiation | STMN2 | D (24–23) | ||||
| Neuronal cell recognition | SLIT2 | U (12–14) | ||||
| Neurotransmitter receptor activity | GABRB3 | U (12–20) | D (22–20) | |||
| Neurotransmitter receptor biosynthesis | PTD009 | U (12–15) | ||||
| Neurotrophin TRKB receptor activity | NTRK2 | U (8–9) | U (16–23) | |||
| Regulation of action potential | SRI | U (19–20) | ||||
| Regulation of neurotransmitter levels | GLUL | U (23–24) | ||||
| Regulation of synapse | NPY | U (18–19) | ||||
| Synaptic transmission | GABRB3 | U (12–20) | D (22–20) | |||
| KCNIP2 | D (18–17) | |||||
| MAPK1 | U (22–23) | |||||
| Synaptic vesicle transport | SYT4 | U (20–23) | ||||
| Total number of genes | 15 | 4 | 3 | 4 | 5 | 1 |
| Total number of GO annotations | 19 | 5 | 6 | 5 | 6 | 1 |
GABA, γ-amino butyric acid; GABAA, GABA type A. U, up-regulated; D, down-regulated. Numbers in parentheses indicate the bin categories spanned by each change.
*
Change on the ancestral African ape node with respect to the ancestral macaque node