Table 4. ETC genes and lineages with significant GO annotations and additional ETC genes and lineages that change unambiguously.
| Complex | Gene | Human | Chimpanzee | Human–chimpanzee | Gorilla | African ape–macaque* |
|---|---|---|---|---|---|---|
| I | GRIM19 | U (21–22) | U (11–21) | |||
| NDUFA2 | D (22–18) | |||||
| NDUFA4 | U (22–24) | |||||
| NDUFA10 | U (21–22) | U (10–21) | ||||
| NDUFA11 | U (11–22) | |||||
| NDUFAB1 | U (19–23) | |||||
| NDUFB1 | U (21–22) | |||||
| NDUFB4 | U (22–23) | |||||
| NDUFB8 | U (3–8) | U (12–23) | ||||
| NDUFC2 | U (22–23) | |||||
| NDUFS4 | U (17–18) | U (15–17) | ||||
| NDUFS6 | U (15–17) | |||||
| III | HSPC051 | U (14–23) | ||||
| UQCRC2 | U (18–20) | D (18–14) | ||||
| UQCRH | U (21–23) | |||||
| IV | COX4I1 | U (20–23) | ||||
| COX5A | U (20–22) | |||||
| COX5B | U (22–23) | U (11–23) | ||||
| COX7C | U (23–24) | |||||
| V | ATP5C1 | U (22–23) | U (21–22) | |||
| ATP5G3 | D (22–20) | |||||
| ATP5H | U (23–24) | |||||
| ATP5J2 | U (20–22) | |||||
| ATP1F1 | N | D (19–11) | ||||
| Other | CYCS | U (23–24) | ||||
| Total genes | 25 | 10 | 6 | 3 | 3 | 11 |
See Results and Tables 6–10 for a full listing of these ETC-related GO annotations. Bold, ETC genes that change unambiguously on one or more relevant branches. U, up-regulated; D, down-regulated. Numbers in parentheses indicate the bin categories spanned by each change.
*
Change on the ancestral African ape node with respect to the ancestral macaque node; N, indeterminate, because different probe sets for the same gene showed opposite directions of change