Table 4.

P53 mutations detected^* in AAI-treated HUFs at p.9-13

Cell line	Codon	Mutation	Description
AA6	209	AGA to TGA	Nonsense (R/Stop) A to T†
AA7	176	TGC to TGG	Missense (C/W) C to G‡
AA13	280	AGA to AGT	Missense (R/S) A to T†
AA18	158	CGC to GGC	Missense (R/G) C to G‡
	int 8	AG to TG	Splice site A to T†
AA22	281	GAC to GTC§	Missense (D/V) A to T†

^*Mutation identified by p53 GeneChip microarray analysis and by DNA sequencing.

^§Detected only by the P53 GeneChip at p.10; detected by both methods at p.20.

^†A:T to T:A transversion.

^‡C:G to G:C transversion.