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S1P receptors are expressed in naïve BMSPCs, and surface expression is reduced after exposure to S1P. Bar graphs showing the expression of S1P receptor 1 and 3 on the surface of BM-derived Lin−/CD34+ stem cells. The graphs show a relatively higher expression of S1P receptors in the BM stem cells that are reduced significantly after 2 h exposure to S1P (250 nM) (*P<0.05 as compared with controls). BM, bone marrow.
