FIG. 6.
Cardiomyocyte electrophysiological recordings. (A–E) Representative If current traces in hESC-CM (60 and 100 days), hF-CM and hAA- and hAV-CM. (F) Activation curves of If current for each cell type (*P<0.05). (G) Effects of membrane cholesterol depletion on activation properties of f-channels in hAA-CM (n=3) and hF-CM (n=6). (H) Bar graph showing mean potential (±SEM) of half maximal activation of f-current (If V1/2) in hAA-CM and hF-CM, treated or not with methyl-β-cyclodextrin (MβCD). ***P<0.001.