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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: Metallomics. 2013 Apr;5(4):372–383. doi: 10.1039/c3mt20217h

Fig. 1. Schematic illustration of the BaeSR regulon.

Fig. 1

The BaeSR regulon encodes three transporters and one periplasmic protein. The membrane-bound BaeS senses environmental signals and transduces them to the transcription activator BaeR, which up-regulates the expression of eight genes on this regulon including baeR and baeS. MdtABC forms a RND-type trans-envelope efflux complex with TolC. MdtD belongs to the major facilitator family for metal transport. AcrD forms another RND-type efflux system in complex with AcrA and TolC. Spy is a periplasmic protein that exhibits ATP-independent chaperone activities in vitro. The regulator BaeS and BaeR are also up-regulated, forming a positive feedback loop to amplify the transcriptional response.