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. 2004 Feb 20;101(9):2975–2980. doi: 10.1073/pnas.0400093101

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Copyright © 2004, The National Academy of Sciences

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Fig. 2. — Foxo1^-/- embryos and yolk sacs show defective vascular development. (A) PECAM-1 immunostaining of whole-mount E9.5 Foxo1^+/+ and Foxo1^-/- embryos, respectively. Note the thin and disorganized dorsal aorta in Foxo1^-/- embryo compared with Foxo1^+/+ embryo (arrowheads). (B) Magnified view of the E9.5 Foxo1^+/+ and Foxo1^-/- intersomitic vessels. Intersomitic vessels in Foxo1^-/- embryo were disorganized compared with Foxo1^+/+ (arrowheads). da, dorsal aorta. (C) Magnified view of the E9.5 Foxo1^+/+ and Foxo1^-/- head vessels. The vessels of the head, including the branches of the internal carotid artery, were properly developed in Foxo1^+/+ but not in Foxo1^-/- embryos (arrowheads). (D) PECAM-1 staining of Foxo1^+/+ and Foxo1^-/- yolk sacs. Properly developed vasculature was present in Foxo1^+/+ yolk sacs but not in Foxo1^-/- yolk sacs.