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. 2004 Feb 20;101(9):2975–2980. doi: 10.1073/pnas.0400093101

Fig. 3.

Fig. 3.

LacZ expression from the insertional targeting vector in heterozygous Foxo+/- embryos and extraembryonic tissues at E11.5. (A) Whole-mount lacZ staining of embryo. LacZ was expressed in several tissues such as the somites (so), branchial arch (ba), heart (h), endolymphatic diverticulum of otocyst (ed), and trigeminal ganglia (V). (B and C) Magnified view of the lacZ stained head and trunk, respectively. Lac Z staining was found in branches of the internal carotid artery (ica), anterior cardinal vein (acv), and intersomitic vessels (isv). (D and E) Whole-mount lacZ staining of the yolk sac and umbilical cord, respectively. Both vitelline vessels and both umbilical vessels were stained. (F-H) LacZ staining for sectioned E11.5 embryo. Various vessels including the capillaries in the neural tube (nt), dorsal aorta (da), posterior cardinal vein (pcv) and intersomitic vessels (isv) were stained. (G) Magnified view of F. so, somite; nc, notocord. (I) Section of lacZ-stained umbilical cord. The endothelial layers of the two vessels (common umbilical artery and vein) were stained.