Table 2.
Cumulative incidence rates of disease-specific survival (DSS) and factors predictive of DSS in primary leiomyosarcoma patients
| Prognostic Factor | N | 5-yr DSS (%) | Univariate P value | Multivariate P value | Hazard Ratio | 95% CI |
|---|---|---|---|---|---|---|
| Age (yrs) | ||||||
| ≤60 | 203 | 77 | 0.104 | – | ||
| >60 | 150 | 66 | ||||
| Sex | ||||||
| Female | 157 | 72 | 0.605 | – | ||
| Male | 196 | 72 | ||||
| Grade | ||||||
| High | 265 | 65 | <0.001 | 0.001 | 3.7 | 1.7–8.2 |
| Low | 88 | 98.5 | ||||
| Size, (cm)a | ||||||
| ≤5 | 155 | 91 | <0.001 | |||
| >5to≤10 | 95 | 71 | 0.049 | 1.8 | 1.0–3.3 | |
| >10 | 99 | 47 | <0.001 | 3.4 | 1.9–6.3 | |
| Depth | ||||||
| Deep | 257 | 66 | <0.001 | 0.076 | 2.0 | 0.9–4.5 |
| Superficial | 96 | 90 | ||||
| Site | ||||||
| Extremity | 170 | 75 | 0.005 | |||
| Abdominal/RP | 144 | 67 | 0.696 | 0.9 | 0.6–1.4 | |
| Trunk | 39 | 81 | ||||
| Margin | ||||||
| Negative | 289 | 74 | 0.226 | – | ||
| Microscopically positive | 52 | 70 | ||||
| Grossly positive | 12 | 42 |
a
size not available for 4 patients