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Cilia disassembly at the G1-S transition. Activation of Aurora A, NIMA kinases and phosphorylation of Tectex-1 induces cilia resorption, whereas activity of Nde1 and INPPE5 blocks this process. The disassembly of cilia triggers phosphorylation and inactivation of pRb leading to cell cycle progression. Aurora A can be activated by PIFO and by inactivation of VHL to regulate cilia disassembly
