Table 3.

Hazards ratios for each specific type of first event across CAC score groups in men and women, adjusted for the occurrence of other possible events.

	MEN			WOMEN
	0 (N=1217)	1–99 (N=905)	≥100 (N =973)	0 (N = 2109)	1–99 (N = 838)	≥100 (N = 539)
	Model 1: Hazards ratio for event (CAC = 0 as referent)			Model 1: Hazards ratio for event ) (CAC = 0 as referent
Non-CVD death	Ref (l.0)	2.01 (1.30, 3.10)	2.78(1.85, 4.17)	Ref (1.0)	1.97(1.27, 3.04)	2.52 (1.58, 4.00)
CHD death/NFMI	Ref (l.0)	3.41 (2.05, 5.65)	8.31 (5.25, 13.2)	Ref (l.0)	2.41 (1.47, 3.97)	6.24 (3.99, 9.75)
Fatal/nonfatal stroke	Ref (l.0)	2.03 (1.03, 3.99)	2.62 (1.39, 4.96)	Ref (1.0)	2.46 (1,39, 4.36)	3.89 (2.20, 6.89)
HF	Ref (l.0)	1.23 (0.52, 2.89)	3.24 (1.61, 6.51)	Ref (1.0)	0.51 (0.11,2.32)	6.45 (2.94, 14.2)
Other CVD death	Ref (l.0)	NA	NA	Ref (1.0)	NA	NA
Model 1: Any CVD event	Ref (l.0)	2.53 (1.77, 3.63)	5.69 (4.13, 7.85)	Ref (1.0)	2.24 (1.57, 3.20)	5.82 (4.23, 8.02)
Model 2: Any CVD Event	Ref (l.0)	2.26 (1.57, 3.25)	4.48 (3.12, 6.42)	Ref (1.0)	1.80 (1.24, 2.63)	3.90 (2.66, 5.73)
Model 3: Any CVD Event	Ref (l.0)	1.99 (1.38, 2.87)	3.65 (2.55, 5.22)	Ref (1.0)	1.63 (1.12, 2.38)	3.18 (2.14, 4.72)

Hazards ratios obtained from Fine and Gray method. Results represent hazards ratios for a given event subtype across CAC score strata (with CAC=0 as the referent), adjusted for the occurrence of other first events.

The model for any CVD event considered possible outcomes of any CVD and non-CVD death only.

Model 1: unadjusted

Model 2: adjusted for age and race

Model 3: adjusted for age, race, systolic blood pressure, total and HDL cholesterol, smoking status, and diabetes CAC = coronary artery calcium, CVD = cardiovascular disease, CHD = coronary heart disease, NFMI = nonfatal myocardial infarction, HF = heart failure