Table 4.
Comparison of hazards ratios from competing models* with standard Cox regression models by CAC in men and women
| Event Type | Hazards ratios in Men | Hazards ratios in Women | |||
|---|---|---|---|---|---|
| Stroke | CAC | Cox regression | Fine and Gray | Cox regression | Fine and Gray |
| 0 | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | |
| 1–99 | 1.81 (0.92,3.56) | 1.53 (0.78,2.99) | 1.60 (0.88,2.93) | 1.52 (0.82,2.82) | |
| ≥ 100 | 1.77 (0.89,3.51) | 1.59 (0.84,3.02) | 1.71 (0.88,3.30) | 1.59 (0.79,3.22) | |
| CHD/NFMI | 0 | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) |
| 1–99 | 2.71 (1.65,4.46) | 2.92 (1.75,4.87) | 1.87 (1.12,3.11) | 1.97 (1.17,3.33) | |
| > 100 | 5.81 (3.61,9.37) | 6.31 (3.82,10.4) | 4.20 (2.52, 7.00) | 4.25 (2.44, 7.40) | |
| Any CVD event | 0 | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) |
| 1–99 | 2.02 (1.40,2.91) | 1.99 (1.38,2.87) | 1.64 (1.13,2.37) | 1.63 (1.12,2.38) | |
| ≥ 100 | 3.68 (2.59, 5.23) | 3.65 (2.55, 5.22) | 3.20 (2.20,4.66) | 3.18 (2.14,4.72) | |
| Non-CVD death | 0 | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) |
| 1–99 | 1.35 (0.87,2.09) | 1.22 (0.78,1.88) | 1.20 (0.76, 1.87) | 1.16 (0.73, 1.82) | |
| ≥ 100 | 1.46 (0.95,2.24) | 1.15 (0.75,1.76) | 1.25 (0.77,2.05) | 1.07 0.64,1.78) | |
denotes that hazards ratios from competing model obtained using the method of Fine and Gray
All hazards ratios adjusted for age, race, systolic blood pressure, total and HDL cholesterol, smoking status, and diabetes
CAC = coronary artery calcium; CHD/NFMI = coronary heart disease/nonfatal myocardial infarction; CVD = cardiovascular disease