Table 2.
Markers of bone turnover at baseline
|
Intermittent ART group
|
Continuous ART group
|
Total
|
||||
|---|---|---|---|---|---|---|
| Marker |
N
|
Median
|
N
|
Median
|
N
|
Median (IQR)
|
| Bone Formation | ||||||
| bALP (μg/L) | 109 | 20.3 | 93 | 18.7 | 202 | 19.6 (16.1, 26.1) |
| Osteocalcin (ng/mL) | 107 | 18.9 | 92 | 17.0 | 199 | 17.6 (13.9, 22.6) |
| P1NP (μg/L) | 109 | 49.4 | 93 | 45.9 | 202 | 47.6 (36.2, 62.1) |
| Bone Resorption | ||||||
| NTX (nM BCE) | 109 | 11.9 | 93 | 10.8 | 202 | 11.3 (9.7, 14.1) |
| βCTX (ng/mL) | 106 | 0.3 | 92 | 0.3 | 198 | 0.3 (0.2, 0.4) |
| Bone Regulators | ||||||
| OPG (pmol/L) | 107 | 4.0 | 90 | 3.8 | 197 | 3.9 (3.3, 4.6) |
| RANKL (pg/mL) | 109 | 7.9 | 91 | 8.6 | 200 | 8.3 (2.0, 23.2) |
| RANKL:OPG ratio | 107 | 2.0 | 89 | 3.2 | 196 | 2.2 (0.6, 6.1) |
| Inflammation | ||||||
| IL-6 (pg/mL) | 109 | 2.0 | 93 | 1.7 | 202 | 1.9 (1.2, 3.0) |
| IL-1 (pg/mL) | 104 | 0.1 | 86 | 0.1 | 190 | 0.1 (0.1, 0.1) |
| TNF-α (pg/mL) | 104 | 9.7 | 86 | 9.2 | 190 | 9.2 (6.7,12.2) |
Abbreviations: bALP, bone-specific alkaline phosphatase; βCTX, C-terminal cross-linking telopeptide of type 1 collagen; IL-1, interleukin lbeta; IL-6, interleukin 6; NTX, N-telopeptide; OPG, Osteoprotegerin; P1NP, procollagen type 1 N terminal propeptide; RANKL, receptor of nuclear factor-KB ligand; TNF-α, tumor necrosis factor α.