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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: J Thorac Cardiovasc Surg. 2013 Feb 8;145(6):1654–1659. doi: 10.1016/j.jtcvs.2013.01.006

Figure 1. Lung function after IR is significantly improved by CCPA.

Figure 1

WT and A1R−/− mice were treated with vehicle or CCPA (doses in mg/kg are shown in parentheses) prior to ischemia. In WT mice after IR, CCPA significantly decreased pulmonary artery pressure and airway resistance and increased pulmonary compliance. Lung function in A1R−/− mice after IR was not significantly different from WT mice after IR, and CCPA did not significantly affect lung function in A1R−/− mice. Lung function was similar between WT and A1R−/− mice after sham surgery (data not shown). *P < 0.03 vs. WT sham, #P < 0.03 vs. WT IR. Means ± SD are shown.