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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: J Thorac Cardiovasc Surg. 2013 Feb 8;145(6):1654–1659. doi: 10.1016/j.jtcvs.2013.01.006

Figure 3. Expression of pro-inflammatory cytokines after IR is attenuated by CCPA.

Figure 3

Cytokine levels in BAL fluid after IR or sham surgery were measured in A1R−/− mice and in WT mice treated with vehicle or CCPA (doses in mg/kg are shown in parentheses) prior to ischemia. Expression of IL-6, CXCL1, CCL2 and TNF-α were all significantly increased after IR in WT mice, and CCPA treatment significantly attenuated cytokine levels after IR. Cytokine levels after IR were elevated in A1R−/− mice after IR similar to WT mice after IR. *P < 0.05 vs. WT sham, #P < 0.05 vs. WT IR. nd = not detectable. Means ± SD are shown.