Table 3.
Mutation patterns of BCP in HBV isolated from patients infected with HBV/C1
| Type | Patterns | |||||||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| V1753 | T1762 | A1764 | T1766 | A1768 | HCC (n=102) | CH (n=105) | P value | |
| wild-type | - | - | - | - | - | 2 (2.0%) | 25 (23.8%) | 0.026 |
| single mutation | + | - | - | - | - | 0 (0%) | 13 (12.4%) | |
| double mutation | - | + | + | - | - | 66 (64.7%) | 54 (51.4%) | 0.802 |
| - | - | - | + | + | 4 (3.9%) | 2 (1.9%) | 0.064 | |
| triple mutation | + | + | + | - | - | 12 (11.8%)* | 4 (3.8%) | 0.022 |
| - | + | + | + | - | 6 (5.9%) | 5 (4.8%) | 0.092 | |
| - | + | + | - | + | 7 (6.9%)* | 3 (2.9%) | 0.039 | |
| quadruple mutation | + | + | + | - | + | 3 (2.9%)* | 1 (0.95%) | 0.041 |
| - | + | + | + | + | 2 (2.0%) | 0 (0%) | ||
HCC, hepatocellular carcinoma; CH, chronic heptitis;
*
P<0.05 comparing the frequency of triple mutation or quadruple mutation in HCC vs. CH.