Table 2.
Plasma lipid profiles of C57BL/6 mice before cholesterol feeding, after five weeks of initial cholesterol feeding and after three additional weeks where the mice were fed the cholesterol-enriched diet supplemented with either formononetin or 2-heptyl-formonetin (C7F) (Experiment 1). Data show mean ± SEM. Different letters (a, b, c, d) denote significant difference (P ≤ 0.05) between the groups.
| Total cholesterol (mmol/L) |
HDL (mmol/L) |
LDL (mmol/L) |
Triglycerides (mmol/L) |
|
|---|---|---|---|---|
| Before test period | ||||
|
| ||||
| After acclimatisation (n = 30) | 3.12 ± 0.20a | 1.39 ± 0.10a | 0.32 ± 0.05 | 1.95 ± 0.55a |
| After initial cholesterol feeding (n = 23) | 3.22 ± 0.26ab | 1.40 ± 0.11ab | 0.35 ± 0.07 | 1.13 ± 0.30ab |
|
| ||||
| After test period | ||||
|
| ||||
| Cholesterol (n = 25) | 3.32 ± 0.25bc | 1.46 ± 0.15b | 0.29 ± 0.06 | 0.95 ± 0.27c |
| Cholesterol + formononetin (n = 23) | 3.43 ± 0.27c | 1.44 ± 0.16ab | 0.34 ± 0.14 | 1.16 ± 0.29b |
| Cholesterol + C7F (n = 25) | 3.83 ± 0.54d | 1.78 ± 0.18c | 0.28 ± 0.10 | 1.03 ± 0.39bc |