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. 2013 Apr 30;2013:541436. doi: 10.1155/2013/541436

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Copyright © 2013 Hui Yu et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Optimization of the flavonoid combination by feedback system control (FSC) scheme. Feedback system control (FSC) scheme was used to optimize the flavonoid combinations. As trial combinations, the drug combinations of four flavonoids were applied onto pHRE-Luc-transfected fibroblasts. The HRE-mediated transcriptional activity was used as the system readout to calculate the fitness of combinations. Differential evolution (DE) algorithm linked the drug combinations and the system readout as to generate new trial combinations in the next iteration.