Fig. 5.
Relationship between hEPO expression in serum and viral copies present in SGs in treated and naïve animals. Mice were killed 8 weeks after administration (n = 4; 109 particles of AAVhEPO per treated animal or 50 μl 0.9% normal saline per naïve animal), and viral copies present in the SGs and serum hEPO levels were measured as described in Materials and Methods. The correlation between viral copies present and serum hEPO levels was highly significant (r = 0.98). The red asterisk indicates the mean hEPO serum levels and mean number of viral copies present in SGs of naïve animals (n = 4).