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GLP-1 abrogates AGE-induced intracellular ROS production. After treatment for 5 days in standard medium (CTR) or in medium containing AGEs (GS) in the presence or absence of 10 nmol/L GLP-1, HIT-T15 cells were prelabeled with DCFH-DA for 30 min and fluorescence was analyzed. Data were expressed as the mean ± SE of four independent experiments. **P < 0.01 and ***P < 0.001 versus CTR; §§ P < 0.01 versus GS.
