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Pharmacological inhibition of proteasome increased accumulation of MafA and PDX-1. HIT-T15 cells were cultured for the last 15 h in the presence or absence of the proteasome inhibitor MG-132, and whole cell extracts were analyzed by western blotting using specific antibodies against PDX-1 and MafA. Actin amounts were analyzed as a loading control. *P < 0.05, **P < 0.01 and ***P < 0.001 versus CTR or versus the same condition without MG132.
