Table 4.

Multivariate Analysis of Predictors of Hospital-Onset CDI (HO-CDI) and Post-Discharge CDI (PD-CDI) Among all Adult Inpatients

	HO-CDI vs. All non HO-CDI		PD-CDI vs. All non HO-CDI
Individual Variables	OR (95% CI)	p-value	OR (95% CI)	p-value
Age		<0.001		<0.001
18 – < 40	Reference		Reference
40 – 49	1.93 (1.29–2.89)		2.20 (1.53–3.17)
50 – 59	1.82 (1.23–2.71)		2.21 (1.54–3.17)
60 – < 75	1.83 (1.28–2.61)		2.76 (1.99–3.82)
75+	2.16 (1.51–3.09)		3.93 (2.85–5.44)
Male Gender	1.04 (0.93–1.16)	0.49	0.87 (0.80–0.95)	0.001
Race		0.01		<0.001
White	Reference		Reference
Black	0.94 (0.61–1.45)		0.49 (0.31–0.78)
Asian	1.27 (1.06–1.52)		0.64 (0.53–0.77)
Other	0.79 (0.59–1.05)		1.04 (0.85–1.28)
Hispanic Ethnicity	0.94 (0.77–1.15)	0.56	0.73 (0.62–0.86)	<0.001
Medicare Insurance	0.61 (0.48–0.77)	<0.001	0.70 (0.56–0.87)	0.001
Admission Year	1.07 (1.05–1.09)	<0.001	1.11 (1.09–1.13)	<0.001
2000 (reference)
2001	1.03 (0.81–1.33)		0.92 (0.75–0.86)
2002	1.12 (0.88–1.43)		1.04 (0.86–1.27)
2003	0.94 (0.73–1.21)		1.14 (0.94–1.38)
2004	1.22 (0.96–1.55)		1.35 (1.12–1.62)
2005	1.25 (0.99–1.58)		1.67 (1.40–1.99)
2006	1.55 (1.24–1.94)		1.83 (1.53–2.18)
2007	1.39 (1.10–1.74)		1.71 (1.43–2.04)
Length of Stay	1.02 (1.02–1.02)	<0.001	1.01 (1.01–1.01)	<0.001
Surgerya	2.16 (1.91–2.43)	<0.001	1.23 (1.12–1.35)	<0.001
Comorbidities
Diabetes	1.36 (1.20–1.53)	<0.001	1.14 (1.03–1.25)	0.009
Cancer	1.32 (1.13–1.55)	<0.001	1.24 (1.09–1.42)	0.001
Dementia	1.57 (1.28–1.93)	<0.001	1.03 (0.87–1.21)	0.74
Ulcer	1.92 (1.49–2.47)	<0.001	1.31 (1.04–1.67)	0.02
AIDS	4.15 (2.02–8.50)	<0.001	3.27 (1.60–6.65)	0.001
High Comorbidity Indexb	1.06 (1.02–1.11)	<0.001	1.02 (1.01–1.03)	0.001
Primary Admission Diagnosis:
Chemotherapy	7.08 (4.04–12.42)	<0.001	----------------------
S.aureus Pneumonia	5.13 (3.23–8.16)	<0.001	----------------------
Infection due to Vascular Device	3.05 (1.87–4.97)	<0.001	----------------------
Septicemia	2.70 (3.71–1.96)	<0.001	3.55 (2.87–4.40)	<0.001
Post-operative Infection	2.36 (3.89–1.43)	<0.001	2.39 (1.51–3.76)	<0.001
Acute Respiratory Failure	2.25 (1.63 – 3.10)	<0.001	----------------------
Pneumonia	1.47 (1.93–1.11)	0.006	1.82 (1.54–2.16)	<0.001
Cellulitis	----------------------		2.41 (1.72–3.38)	<0.001
Colon Diverticulitis	----------------------		2.37 (1.64–3.43)	<0.001
Urinary Tract Infection	----------------------		1.86 (1.48–2.33)	<0.001
Acute Renal Failure	----------------------		1.73 (1.25–2.39)	<0.001

^aSurgery indicates surgery during the current admission or within the previous 30 days

^bComorbidity Index measured by Romano score