Figure 2.
Weekly arterial blood pressure and heart rate profiling by telemetry in congenic mRen2.Lewis rats. Olmesartan (Olm) reduced blood pressure in congenic rats from the first week of the treatment (P < 0.05 vs. control and mas receptor antagonist [D-ALA7]-Ang-(1–7) (A-779)). Coadministration of A-779 did not affect the blood pressure–lowering effects of olmesartan nor did the treatment with A-779 alone induce any change in blood pressure. The profound antihypertensive effect of olmesartan was associated with an increase in heart rate in olmesartan and olmesartan + A-779 (P < 0.05 vs. control and A-779) that returned to the pretreatment values after the first week of treatment. Values are mean ± SEM. n = 7 per group. *P < 0.0.5 vs. control; ‡P < 0.0.5 vs. A-779.