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Angiotensin converting enzyme (ACE), ACE2, and neprilysin (NEP) activities in kidney of mRen2.Lewis rats treated with AT1 and mas receptor antagonists
| Enzyme | Control | A-779 | OLM | OLM + A-779 |
|---|---|---|---|---|
| ACE, nmol/mg/min | 1.9±0.6 | 2.5±0.3 | 2.4±0.9 | 2.0±0.8 |
| ACE2, fmol/mg/min | 32.0±1.7 | 30.6±1.0 | 36.7±1.7 | 34.4±1.9 |
| NEP, fmol/mg/min | 95.5±2.9 | 105.0±4.1 | 100.9±4.7 | 97.5±4.3 |
Values are mean ± SEM. A-779, mas receptor antagonist [D-ALA7]-Ang-(1–7). Abbreviation: OLM, olmesartan.
