Table 3.
Blood pressure responses to dietary sodium interventions according to DDAH1, VWF, and COL18A1 genotypes
| HGNC symbol | Genotype | No. | Response to low-sodium intervention (95% CI) | P | Q | Response to high-sodium intervention (95% CI) | P | Q | |
|---|---|---|---|---|---|---|---|---|---|
| Systolic blood pressure | |||||||||
| DDAH1 | rs11161637 | A/A | 1021 | −6.20 (−6.70 to −5.70) | 0.0002 | 0.05 | 4.98 (4.56–5.40) | 0.006 | 0.66 |
| A/G | 732 | −5.38 (−5.87 to −4.88) | 4.04 (3.60–4.48) | ||||||
| G/G | 128 | −4.02 (−5.33 to −2.70) | 4.38 (3.29–5.47) | ||||||
| VWF | rs2239153 | T/T | 681 | −5.12 (−5.65 to −4.60) | 0.0009 | 0.13 | 4.15 (3.68–4.62) | 0.001 | 0.39 |
| T/C | 821 | −6.06 (−6.61 to −5.52) | 4.62 (4.19–5.05) | ||||||
| C/C | 275 | −6.54 (−7.40 to −5.68) | 5.57 (4.82–6.32) | ||||||
| COL18A1 | rs2838944 | G/G | 1605 | −5.73 (−6.14 to −5.33) | 0.90 | 0.94 | 4.69 (4.35–5.02) | 0.01 | 0.94 |
| G/A | 263 | −5.69 (−6.55 to −4.83) | 3.89 (3.19–4.60) | ||||||
| A/A | 9 | −7.21 (−13.36 to −1.05) | 2.00 (−0.50–4.49) | ||||||
| Diastolic blood pressure | |||||||||
| DDAH1 | rs11161637 | A/A | 1021 | −3.01 (−3.43 to −2.60) | 0.002 | 0.16 | 1.97 (1.61–2.32) | 0.005 | 0.27 |
| A/G | 732 | −2.46 (−2.87 to −2.05) | 1.28 (0.88–1.69) | ||||||
| G/G | 128 | −1.66 (−2.64 to −0.68) | 1.17 (0.21–2.13) | ||||||
| VWF | rs2239153 | T/T | 681 | −2.13 (−2.55 to −1.72) | 0.0001 | 0.03 | 1.32 (0.89–1.74) | 0.004 | 0.24 |
| T/C | 821 | −3.09 (−3.54 to −2.64) | 1.82 (1.43–2.20) | ||||||
| C/C | 275 | −3.38 (−4.08 to −2.67) | 2.34 (1.71–2.96) | ||||||
| COL18A1 | rs2838944 | G/G | 1605 | −2.70 (−3.05 to −2.36) | 0.78 | 0.89 | 1.83 (1.52–2.14) | 0.0001 | 0.04 |
| G/A | 263 | −2.70 (−3.39 to −2.02) | 0.65 (0.00 –1.29) | ||||||
| A/A | 9 | −4.16 (−7.30 to −1.02) | −1.03 (−3.45 to 1.38) | ||||||
| Mean arterial pressure | |||||||||
| DDAH1 | rs11161637 | A/A | 1021 | −4.08 (−4.47 to −3.69) | 0.0002 | 0.02 | 2.97 (2.63 to 3.31) | 0.001 | 0.13 |
| A/G | 732 | −3.43 (−3.83 to −3.04) | 2.20 (1.83–2.57) | ||||||
| G/G | 128 | −2.45 (−3.42 to −1.48) | 2.24 (1.35–3.12) | ||||||
| VWF | rs2239153 | T/T | 681 | −3.13 (−3.54 to −2.73) | 4.4×10–5 | 0.01 | 2.26 (1.87–2.66) | 0.0007 | 0.09 |
| T/C | 821 | −4.08 (−4.51 to −3.65) | 2.75 (2.40–3.10) | ||||||
| C/C | 275 | −4.43 (−5.11 to −3.76) | 3.41 (2.83–4.00) | ||||||
| COL18A1 | rs2838944 | G/G | 1605 | −3.72 (−4.04 to −3.40) | 0.82 | 0.97 | 2.78 (2.50–3.07) | 0.0002 | 0.04 |
| G/A | 263 | −3.70 (−4.37 to −3.03) | 1.72 (1.13–2.31) | ||||||
| A/A | 9 | −5.16 (−9.12 to −1.20) | −0.04 (−1.81 to 1.72) | ||||||
Abbreviations: CI, confidence interval; COL18A1, collagen, type XVIII, alpha 1; DDAH1, dimethylarginine dimethylaminohydrolase 1; HGNC, Human Genome Nomenclature Committee; VWF, von Willebrand factor.