Table 1.
Demographic Characteristics in 207 Cases of Candida Osteomyelitis
| Characteristic | No. (%) |
|---|---|
| Median age (neonates–88 years)a | 30 years |
| Adults (≥19 years) | 164 (79) |
| Pediatric population | 37 (18) |
| Neonates (<1 months) | 11 (5) |
| Infants (<12 months) | 15 (7) |
| Children (1 year–18 years) | 11 (5) |
| Sex | |
| Females | 58 (28) |
| Males | 146 (71) |
| Unknown | 3 (1) |
| Underlying conditions | |
| Solid tumors | 19 (9) |
| Hematologic malignancy | 17 (8) |
| Solid organ transplantation | 5 (2) |
| Bone marrow transplantation | 5 (2) |
| Surgery | |
| Facial/neck | 6 (3) |
| Thoracicb | 31 (15) |
| Abdominalc | 47 (23) |
| Orthopedicd | 23 (11) |
| Prior broad-spectrum antibiotics | 115 (56) |
| Prior antifungal agents | 59 (29) |
| Central catheter | 78 (38) |
| Open fracture | 3 (1) |
| Trauma/open wound | 20 (10) |
| Neutropenia | 21 (10) |
| Corticosteroids | 28 (14) |
| Pharmacological immunosuppression other than corticosteroids | 24 (12) |
| Total parenteral nutrition | 39 (19) |
| Intravenous drug use | 29 (14) |
| Intensive care unit | 27 (13) |
| Alcohol abuse | 12 (6) |
| Metal hardware/prosthesis | 11 (5) |
| Human immunodeficiency virus | 7 (3) |
| Hemodialysis | 7 (3) |
| Previous bacterial osteomyelitis | 4 (2) |
| Osteomyelitis as first proven site of candidiasis | 100 (48) |
| Preceding Candida infection | 107 (52) |
| Candidemia | 57 (28) |
| Cutaneous and subcutaneous infection | 61 (29) |
| Central catheter | 35 (17) |
| Endocarditis | 3 (1) |
| Candiduria | 22 (11) |
| Eye | 12 (6) |
| Abdominal cavity | 11 (5) |
| Othere | 22 (11) |
a Six cases (3%) had lack of the age data point.
b Nineteen patients underwent sternotomy.
c Twelve patients had abdominal abscess and 8 had gastrointestinal rupture.
d Six patients underwent laminectomy.
e Oral cavity, lymph nodes, lungs, mediastinum, uterus, and liver.