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. Author manuscript; available in PMC: 2013 May 19.
Published in final edited form as: Circulation. 2008 Sep 30;118(14 0):S226–S233. doi: 10.1161/CIRCULATIONAHA.107.760785

Figure 4. Evaluation of cardiac function in infarcted mice following shRNA therapy.

Figure 4

(a) Representative echocardiogram (M-mode) of mice with LAD ligation following injection of shScramble plasmid (upper panel) versus shPHD2 plasmid (lower panel) at pre-surgery, week 2, week 4 and week 8. (b) Quantitative analysis of left ventricular fractional shortening (LVFS) between the two groups. Animals injected with shPHD2 had significant improvement in LVFS at week 4 but not at week 8.