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. Author manuscript; available in PMC: 2014 Apr 16.
Published in final edited form as: Neuroscience. 2013 Jan 16;236:160–185. doi: 10.1016/j.neuroscience.2013.01.015

Table 3.

The two tryptophan hydroxylase isoforms, their location and corresponding physiological and pathological function of central or peripheral serotonin systems

Tryptophan hydroxylase isoform
TPH1 TPH2
Location
Enterochromaffin cells, pineal body Brain
Physiological functions of serotonin
Melatonin synthesis Food intake and body weight
Vasoconstriction Sleep
Haemostasis Behavior
Immune system Mood
Intestinal motility Thermoregulation
Serotonin in pathology of diseases
Migraine Migraine
Carcinoid Neuropsychiatric disorders
Obesity