Skip to main content
. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: Arch Biochem Biophys. 2013 Feb 28;535(1):10.1016/j.abb.2013.02.006. doi: 10.1016/j.abb.2013.02.006

FIGURE 6.

FIGURE 6

Disruption of cTnC variants I61Q and L57Q on the interactions between helices B (residues 41-48) and C (residues 54-64) of cNTnC. WT (shown in panel A) simulations results suggest that the following residues pairs between helices B and C were in contact during more than 30% of the total simulation time: L41 vs. L57, L41 vs. M60, L41 vs. I61, G42 vs. L57, M45 vs. L57, and M45 vs. M60. For L57Q (shown in panel B), contact time between M45 and Q57 was decreased for 26% compared to WT; For I61Q (shown in panel C), contact time between all the pairs listed above were decreased (L41 vs. L57 ↓6%; L41 vs. M60 ↓ 9%; L41 vs. Q61↓ 15%; G42 vs. L57 ↓17%, M45 vs. L57↓2%, and M45 vs. M60 ↓10%.) compared to WT.