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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: J Diabetes. 2013 May 28;5(3):233–240. doi: 10.1111/1753-0407.12027

Fig. 2. FoxO mediates insulin action on target gene expression.

Fig. 2

A. FoxO1 binds to the insulin response element (IRE) within the target promoter and promotes target gene expression in the absence of insulin. B. FoxO1 becomes phosphorylated in response to insulin. This effect promotes FoxO1 nuclear exclusion, resulting in the inhibition of target gene expression. N, nucleus. C, cytoplasm.