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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: J Diabetes. 2013 May 28;5(3):233–240. doi: 10.1111/1753-0407.12027

Fig. 3. Schematic depiction of mouse FoxO1 and FoxO6 proteins.

Fig. 3

FoxO1 and FoxO6 are characterized by the amino DNA binding motif and carboxyl trans-activation domain. They share a conserved bipartite basic nuclear localization signal (NLS) within the DNA binding domain. FoxO1 contains a nuclear export signal (NES) within its carboxyl trans-activation domain. Such a characteristic motif is lacking in FoxO6. FoxO1 contains three Akt/PKB phosphorylation sites (T24, S253, and S316). In contrast, only two Akt/PKB phosphorylation sites (T26 and S184) are present in FoxO6.