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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: J Diabetes. 2013 May 28;5(3):233–240. doi: 10.1111/1753-0407.12027

Fig. 5. A model of FoxO1 nucleocytoplasmic shuttling.

Fig. 5

A. FoxO1 contains a conserved NES within the trans-activation domain. In contrast, FoxO6 contains a semi-conserved NES. B. FoxO1 upon phosphorylation is associated with CRM-1, an exportin that is responsible for transporting FoxO1 from the nucleus to the cytoplasm.