Table 1.
Metabolic phenotyping and chemistries of mice fed control or ethanol diets for two, four or eight weeks
Data are reported as means ± SEM and compared by t test; n = 10/group. P<0.05 is considered significant.
| Metabolic parameters | 2 wks | 4 wks | 8 wks | ||||||
|---|---|---|---|---|---|---|---|---|---|
| CTRL | ETOH | P | CTRL | ETOH | P | CTRL | ETOH | P | |
| Body weight (g) | 27.3 ± 0.5 | 26.4 ± 0.4 | 0.19 | 27.1 ± 0.7 | 26.8 ± 0.5 | 0.73 | 32.3 ± 1.1 | 31.0 ± 0.6 | 0.26 |
| Energy intake (kcal/mouse/day) | 13.9 ± 0.1 | 13.8 ± 0.4 | 0.73 | 13.5 ±0.1 | 13.5 ±0.1 | 0.83 | 14 ± 0.1 | 14.0 ± 0.2 | 0.89 |
| Activity (counts) | 8570 ±28 | 9415 ±1225 | 0.79 | 8125 ± 533.4 | 6739 ±1572 | 0.43 | ---- | ---- | ---- |
| V̇o2 (mL/h) | 82.1 ± 6.1 | 83.9 ± 6.4 | 0.84 | 89.1 ± 7.0 | 85.4 ± 7.2 | 0.72 | ---- | ---- | ---- |
| RQ | 0.71 ± 0.002 | 0.71 ± 0.003 | 0.55 | 0.71 ± .004 | 0.72 ± 0.005 | 0.37 | ---- | ---- | ---- |
| %Fat | 12.2 ±2.7 | 12.7 ±1.6 | 0.88 | 13.1 ±0.7 | 10.3 ±2.1 | 0.20 | 18.3 ±1.9 | 19.8 ± 2.2 | 0.62 |
| %Lean | 86.3 ±2.6 | 85.2 ±1.5 | 0.71 | 83.5 ±1.3 | 88.4 ±2.3 | 0.10 | 81.4 ±1.5 | 78.9 ± 2.1 | 0.35 |
| Chemistries | |||||||||
| Blood glucose (mg/dL) | 145 ±7.6 | 136 ±7.9 | 0.44 | 149 ±4.0 | 152 ±5.1 | 0.60 | 126 ±15.9 | 164 ±21.0 | 0.19 |
| Serum insulin (ng/mL) | 0.81 ±0.1 | 0.57 ±0.2 | 0.27 | 0.77 ±0.2 | 1.27 ±0.2 | 0.14 | 1.97 ±0.5 | 1.27 ±0.2 | 0.16 |
| Serum ALT (IU/L) | 15 ±3.3 | 12 ±1.5 | 0.47 | 16 ±1.2 | 17 ±1.0 | 0.42 | 9 ±3.7 | 13 ±3.3 | 0.46 |
| Serum TG (mg/dL) | 87 ±6.0 | 95 ±1.9 | 0.27 | 93 ±3.7 | 94.52 ±7.4 | 0.82 | 70 ± 5.4 | 78 ±6.0 | 0.34 |
| Liver TG (mg/g tissue) | 40 ±7.0 | 29 ±6.4 | 0.31 | 34 ±5.5 | 59 ±9.0 | 0.04 | 62 ±2.9 | 76 ±25.3 | 0.65 |
CTRL= control-fed mice; ETOH= ethanol-fed mice; Vo 2= oxygen consumption; RQ=Respiratory quotient; ALT=alanine aminotransferase TG=triglyceride.