Table 4.
Path A | Path B | Path C | Path C′ | ||||
---|---|---|---|---|---|---|---|
Depressionb → Ovarian Fxc | Ovarian Fxc → Cardio-metabolic Riskd | Depressionb → Cardio-metabolic Riskd (unadjusted for ovarian function) | Depressionb → Cardio-metabolic Riskd (adjusted for ovarian function) | ||||
b | p | b | p | b | p | b | p |
.990 | .001 | 0.125 | .040 | 0.152 | .040 | 0.129 | .083 |
Analyses included covariate-adjustment for age, race/ethnicity, SES, smoking, physical activity level, parity, past use of hormone-containing medication for birth control, menstrual cycle length, and AMH.
Depression was represented by the lifetime history of depression composite score coded having received a depression diagnosis or having used anti-depressant medications (yes/no).
Ovarian function was indexed by change in menstrual cycle length coded any change vs. no change.
Cardio-metabolic risk was represented by the cardio-metabolic risk composite score reflecting the mean of standardized values of 5 individual risk factors (HDL, triglycerides, waist circumference, glucose, hypertensive status) with HDL reversed.