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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: Magn Reson Med. 2013 Feb 7;70(6):10.1002/mrm.24597. doi: 10.1002/mrm.24597

Figure 7. Ex vivo micro-MRI for high-resolution imaging of Fl-Pfl.

Figure 7

(a) Ex vivo micro-MRI of the P28 wildtype mouse brain provided detailed visualization of the foliation pattern in the cerebellum, including the flocculus-paraflocculus (Fl-Pfl) (shown in the dashed box). (b) Matching histology (stained with H&E) and (c) micro-MRI (magnified view corresponding to the dashed box in panel a), and showed good (qualitative) correlation between the non-enhanced inner region on MRI and the combined white matter (WM) and internal granule cell (IGL) layers, and between the enhanced outer region on MRI and the molecular layer (ML). 3D reconstruction of the inner non-enhanced (WM and IGL) from ex vivo micro-MRI provided excellent visualization of the foliation patterns in (d) the cerebellum proper (shown bisected along the midline), as well as (e) the Fl-Pfl (viewed in a similar orientation as the section in panel c). Labels: hemispheres, H; vermis, V.