Table 1.
NMNAT1 mutations and clinical phenotypes in individuals with LCA
MOGL number | Age (years) | Allele 1 | Allele 2 | Clinical information | Nationality |
---|---|---|---|---|---|
208 | 56 | c.769G>A (p.Glu257Lys) | c.817A>G (p.Asn273Asp) | NLP and CF vision, hyperopia, nystagmus, pseudophakia | French Canadian |
512 | 13 | c.619C>T (p.Arg207Trp) | c.769G>A (p.Glu257Lys) | CF vision, hyperopia, nystagmus | French Canadian |
1269 | N/A | c.451G>A (p.Val151Phe) | c.769G>A (p.Glu257Lys) | N/A | European |
624 | 10 | c.769G>A (p.Glu257Lys) | c.769G>A (p.Glu257Lys) | NLP vision, hyperopia, nystagmus | Saudi Arabian |
3174 | 33 | c.507G>A (p.Trp169*) | c.710G>T (p.Arg237Leu) | 20/2000 vision, hyperopia, nystagmus | Irish |
3294 | 41 | c.199G>T (p.Val67Phe) | c.769G>A (p.Glu257Lys) | CF vision, hyperopia, nystagmus | Russian |
3698 | 10 | c.37G>A (p.Ala13Thr) | c.293T>G (p.Val98Gly) | CF vision, hyperopia, nystagmus | Haitian (African descent) |
LCA9 | 2–30 | c.838T>C (p.*280Gln) | c.838T>C (p.*280Gln) | LP vision, congenital visual loss, nystagmus, nyctalopia, all (n = 8) have acquired macular colobomas, cataracts (PSCC), white retinal dots, retinal pigment, one has keratoconus | Pakistani |
All patients have macular colobomas. NLP, no light perception; LP, light perception; CF, counting fingers; N/A, not available.