Table 1.
Clinicopathologic Factors of Patients With Pancreatic Adenocarcinoma According to BRCA Mutation Status
| Characteristic | Total (N = 145) |
BRCA (n = 8) |
P | ||||
|---|---|---|---|---|---|---|---|
| No. | % | No. | % | ||||
| Median age, years | 71 | 66 | |||||
| Range | 42-84 | 60-79 | NS | ||||
| Female sex | 60 | 41 | 4 | 50 | NS | ||
| Pain | 45 | 31 | 4 | 50 | NS | ||
| Jaundice | 46 | 32 | 1 | 13 | NS | ||
| Surgery | NS | ||||||
| Pancreaticoduodenectomy | 126 | 87 | 6 | 75 | |||
| Distal pancreatectomy | 16 | 11 | 1 | 13 | |||
| Total pancreatectomy | 3 | 2 | 1 | 13 | |||
| Margin positive | 39 | 27 | 4 | 50 | NS | ||
| Median size, cm | 3.3 | 3.5 | NS | ||||
| Range | 1.8-2 | 3.1-7 | |||||
| Perineural invasion | 107 | 74 | 5 | 62 | NS | ||
| Perivascular invasion | 55 | 38 | 3 | 38 | NS | ||
| Tumor location | NS | ||||||
| Head | 127 | 87 | 6 | 75 | |||
| Body | 7 | 5 | 2 | 25 | |||
| Tail | 11 | 8 | |||||
| Differentiation | NS | ||||||
| Well | 16 | 11 | 0 | 0 | |||
| Moderate | 77 | 53 | 4 | 50 | |||
| Poor | 44 | 30 | 2 | 25 | |||
| Unknown | 8 | 6 | 2 | 25 | |||
| Stage of resected patients | NS | ||||||
| IA | 3 | 2 | 0 | 0 | |||
| IB | 23 | 16 | 0 | 0 | |||
| IIA | 27 | 19 | 3 | 38 | |||
| IIB | 89 | 61 | 5 | 62 | |||
| IV | 3 | 2 | 0 | 0 | |||
| Adjuvant chemotherapy | 58 | 40 | 2 | 25 | NS | ||
| Adjuvant radiation | 40 | 28 | 2 | 25 | NS | ||
| Vital status as last follow up | NS | ||||||
| NED | 6 | 4 | 0 | 0 | |||
| AWD | 4 | 3 | 1 | 13 | |||
| DOD | 125 | 86 | 7 | 87 | |||
| DOC | 12 | 7 | 0 | 0 | |||
Abbreviations: NS, not significant; NED, no evidence of disease; AWD, alive with disease; DOD, dead as a result of disease; DOC, dead as a result of another cause.