Table 1.
List of genes that are expressed either lower or higher in aged than in young T cells.
| Down-regulated |
Up-regulated |
||||
|---|---|---|---|---|---|
| Genes | Subsets | Reference | Genes | Subsets | Reference |
| T cell receptor signaling pathway | Cytokine/chemokine network | ||||
| AKT3 | h CD8 | Cao et al. (2010) | ACVR2A, IL15, TNFSF14 | h CD8 | Cao et al. (2010) |
| CD28 | h CD4N, CD8CD28- | Weng et al. (2009), Czesnikiewicz-Guzik et al. (2008) | Bmpr1a | m CD4N, CD8N | Mirza et al. (2011) |
| CD3G | h CD8 | Cao et al. (2010) | Ccl1, Il5, Il9, Il3, Il21 | m s-CD4N & CD8N | Mirza et al. (2011) |
| DLG1 | h CD8 | Cao et al. (2010) | Ccl17, Ccl20, Ccl22, Ccl24 | m s-CD4N | Mirza et al. (2011) |
| GRAP2 | h CD8 | Cao et al. (2010) | Ccl21c, Ccl8, Csf2 | m CD8N | Mirza et al. (2011) |
| GRB2 | h CD8CD28- | Lazuardi et al. (2009) | CCL3/Ccl3 | h CD4, m CD4N | Mirza et al. (2011), Chen et al. (2003) |
| ITK | h CD8 | Cao et al. (2010) | CCL4 | h CD8CD28- | Fann et al. (2005) |
| LCK | h CD8 | Cao et al. (2010) | CCL5/Ccl5 | h CD8, m CD4N, CD8N | Cao et al. (2010), Mirza et al. (2011) |
| MAPK1, MAPK14 | h CD8 | Cao et al. (2010) | CCR1 | h CD4 | Mo et al. (2003), Yung and Mo (2003) |
| NCK1 | h CD8 | Cao et al. (2010) | CCR2/Ccr2 | h CD4, m CD4N, CD8N | Mirza et al. (2011), Mo et al. (2003) |
| PDK1 | h CD8CD28- | Lazuardi et al. (2009) | CCR3 | h CD4 | Yung and Mo (2003) |
| PIK3CD | h CD8CD28- | Lazuardi et al. (2009) | CCR4/Ccr4 | h CD4, CD4N, m CD4N, s-CD8N | Czesnikiewicz-Guzik et al. (2008), Mirza et al. (2011), Mo et al. (2003), Yung and Mo (2003) |
| SOS2 | h CD8 | Cao et al. (2010) | CCR5/Ccr5 | h CD4, CD4N, m CD4N/CD8N | Czesnikiewicz-Guzik et al. (2008), Mirza et al. (2011), Mo et al. (2003), Yung and Mo (2003) |
| CCR6, CXCR2, CXCR5 | h CD4 | Mo et al. (2003) | |||
| Cytokine/chemokine network | CCR8 | h CD4N | Czesnikiewicz-Guzik et al. (2008), Mo et al. (2003) | ||
| Ccl19 | m s-CD4N | Mirza et al. (2011) | CD70, IL17RB | h CD4N | Czesnikiewicz-Guzik et al. (2008) |
| Ccl22 | m CD8N | Mirza et al. (2011) | CLCF1 | h CD8CD28- | Lazuardi et al. (2009) |
| Ccl24 | m s-CD8N | Mirza et al. (2011) | Csd2, Cxcl11 | m s-CD4N | Mirza et al. (2011) |
| Ccr9 | m CD4N, CD8N | Mirza et al. (2011) | Csf1, Cxcl10 | m CD4N | Mirza et al. (2011) |
| Cxcl1 | m CD4N | Mirza et al. (2011) | Csf2ra, Cxcl2 | m CD8N | Mirza et al. (2011) |
| Cxcl10, Cxcl12 | m CD8N | Mirza et al. (2011) | Csf3r | m s-CD8N | Mirza et al. (2011) |
| CXCR7, CXCR9 | h CD4, CD8 | Mo et al. (2003) | CX3CR1 | h CD8CD28- | Lazuardi et al. (2009), Fann et al. (2005) |
| Flt1 | m s-CD8N | Mirza et al. (2011) | CXCL12 | h CD4 | Hernandez-Lopez et al. (2010), Cane et al. (2012) |
| Ifna1 | m CD8N, s-CD4N | Mirza et al. (2011) | Cxcl9 | m CD8N, s-CD4N | Mirza et al. (2011) |
| Ifna13 | m CD8N | Mirza et al. (2011) | CXCR3/Cxcr3 | h CD4, CD8, m CD4N, CD8N | Cao et al. (2010), Mirza et al. (2011), Mo et al. (2003) |
| Ifnab | m CD4N | Mirza et al. (2011) | CXCR4 | h CD4 | Mo et al. (2003), Hernandez-Lopez et al. (2010), Cane et al. (2012) |
| Il12b, Kit, Pdgfb | m s-CD4N | Mirza et al. (2011) | FAS, IFNGR1 | h CD8CD28- | Lazuardi et al. (2009) |
| Cytokine/chemokine network | Cytokine/chemokine network | ||||
| Il12rb2 | m s-CD8N | Mirza et al. (2011) | Ifng, Il10, Il4 | m CD4N, CD8N | Mirza et al. (2011) |
| Il17a, Il6 | m s-CD8N | Mirza et al. (2011) | Il12rb1, Il13, Il5ra | m CD4N | Mirza et al. (2011) |
| Il6ra | m CD4N | Mirza et al. (2011) | Il18r1, Il20ra, Il23r, Il7r | m s-CD8N | Mirza et al. (2011) |
| Kit | m s-CD8N | Mirza et al. (2011) | Il18rap, Il1b | m CD8N | Mirza et al. (2011) |
| Ppbp | m CD4N | Mirza et al. (2011) | Il19, Il24, Il2ra, Inhba | m s-CD4N | Mirza et al. (2011) |
| Tnfrsf21 | m s-CD8N | Mirza et al. (2011) | Il1r2 | m CD4N, s-CD4N, CD8N | Mirza et al. (2011) |
| Tnfsf11a | m CD8N | Mirza et al. (2011) | Il2, Il22, Il23a | m s-CD8N | Mirza et al. (2011) |
| Tpo | m s-CD8N | Mirza et al. (2011) | Ltbr | m CD4N, CD8N | Mirza et al. (2011) |
| Xcr1 | m CD4N, s-CD8N | Mirza et al. (2011) | Tnfrsf13c | m CD4N | Mirza et al. (2011) |
| Natural killer cell-mediated cytotoxicity | Tnfsf13b, Tnfsf4, Tnfrsf17 | m CD4N, CD8N | Mirza et al. (2011) | ||
| Ifna1 | m s-CD4N | Mirza et al. (2011) | |||
| Klrd1, Klrk1 | m s-CD4N | Mirza et al. (2011) | Natural killer cell-mediated cytotoxicity | ||
| Nfatc4 | m s-CD4N | Mirza et al. (2011) | CD244 | h CD8 | Cao et al. (2010) |
| FAS | h CD8CD28- | Lazuardi et al. (2009) | |||
| Toll like receptor signaling pathway | GZMB | h CD8CD28- | Lazuardi et al. (2009) | ||
| Cd86 | m CD8N | Mirza et al. (2011) | IFNGR1 | h CD8CD28- | Lazuardi et al. (2009) |
| Cxcl10 | m CD8N | Mirza et al. (2011) | ITGB2 | h CD8 | Cao et al. (2010) |
| Ifna1, Ifna13 | m CD8N | Mirza et al. (2011) | KIR2DL3, KIR2DL4 | h CD4N | Czesnikiewicz-Guzik et al. (2008) |
| Ifnab | m CD4N | Mirza et al. (2011) | KIR2DL5A | h CD8CD28- | Lazuardi et al. (2009) |
| Il6 | m s-CD8N | Mirza et al. (2011) | KIR2DS5 | h CD8CD28- | Lazuardi et al. (2009) |
| Irf7 | m CD4N, s-CD8N | Mirza et al. (2011) | KIR3DL1 | h CD8CD28- | Lazuardi et al. (2009) |
| Lbp | m CD4N | Mirza et al. (2011) | KIR3DL2 | h CD4N, CD8CD28- | Czesnikiewicz-Guzik et al. (2008), Lazuardi et al. (2009) |
| Pik3cd | m CD4N | Mirza et al. (2011) | KLRC3 | h CD8CD28- | Lazuardi et al. (2009) |
| Rela | m CD4N | Mirza et al. (2011) | KLRD1 | h CD8 | Cao et al. (2010) |
| Tlr5, Tlr7 | m s-CD8N | Mirza et al. (2011) | KLRG1 | h CD8 | Henson and Akbar (2009) |
| MAPK1 | h CD8CD28- | Lazuardi et al. (2009) | |||
| Cell cycle regulator | NKG2D | h CD4 | Alonso-Arias et al. (2011) | ||
| CCND2, CCNH | h CD8 | Cao et al. (2010) | PRF1 | h CD8CD28- | Lazuardi et al. (2009) |
| FZR1 | h CD8 | Cao et al. (2010) | PTPN6 | h CD8 | Cao et al. (2010) |
| MAD1L1 | h CD8 | Cao et al. (2010) | VAV3 | h CD8CD28- | Lazuardi et al. (2009) |
| MYC | h CD8 | Cao et al. (2010) | |||
| RAD21 | h CD8 | Cao et al. (2010) | MAPK signaling pathway | ||
| RB1, RBL2 | h CD8 | Cao et al. (2010) | DUSP2, DUSP5,DUSP6, DUSP10 | h CD8 | Cao et al. (2010) |
| SMAD2, SMAD4 | h CD8 | Cao et al. (2010) | DUSP4 | h CD8CD28- | Lazuardi et al. (2009) |
| SMC3 | h CD8 | Cao et al. (2010) | FAS | h CD8CD28- | Lazuardi et al. (2009) |
| STAG1 | h CD8 | Cao et al. (2010) | FGFR1 | h CD8 | Cao et al. (2010) |
| TFDP2 | h CD8 | Cao et al. (2010) | FLNA | h CD8 | Cao et al. (2010) |
| YWHAE, YWHAZ | h CD8 | Cao et al. (2010) | GNA12 | h CD8 | Cao et al. (2010) |
| MAP3K1 | h CD8CD28- | Lazuardi et al. (2009) | |||
| Insulin signaling pathway | MAP3K5 | h CD8 | Cao et al. (2010) | ||
| AKT3 | h CD8 | Cao et al. (2010) | MAP3K8 | h CD8 | Cao et al. (2010) |
| BRAF | h CD8 | Cao et al. (2010) | MAP4K1 | h CD8 | Cao et al. (2010) |
| FLOT2 | h CD8 | Cao et al. (2010) | MAPK1 | h CD8CD28- | Lazuardi et al. (2009) |
| FOXO1 | h CD8 | Cao et al. (2010) | NR4A1 | h CD8 | Cao et al. (2010) |
| GRB2 | h CD8CD28- | Lazuardi et al. (2009) | RPS6KA5 | h CD8 | Cao et al. (2010) |
| Insulin signaling pathway | MAPK signaling pathway | ||||
| IRS1, IRS2 | h CD8 | Cao et al. (2010) | RRAS2 | h CD8CD28- | Lazuardi et al. (2009) |
| MAPK1 | h CD8 | Cao et al. (2010) | |||
| PDE3B | h CD8 | Cao et al. (2010) | Toll like receptor signaling pathway | ||
| PIK3CD | h CD8CD28- | Lazuardi et al. (2009) | Ccl3 | m CD4N | Mirza et al. (2011) |
| PIK3R2 | h CD8 | Cao et al. (2010) | Ccl5 | m CD4N | Mirza et al. (2011) |
| PRKACB, PRKAR1A | h CD8 | Cao et al. (2010) | Cd86 | m CD4N | Mirza et al. (2011) |
| RPS6KB1 | h CD8 | Cao et al. (2010) | Cxcl10 | m CD4N | Mirza et al. (2011) |
| SOS2 | h CD8 | Cao et al. (2010) | Tlr4 | m CD4N | Mirza et al. (2011) |
h, Human; m, mouse; CD4N, CD4 naïve T cells; CD8N, CD8 naïve T cells; s-, TCR activated.