Figure 5.

Intra-iFC in the left anterior insula within the salience network is associated with increased SN-CEN interaction and severity of negative symptoms. Intrinsic functional connectivity (inter-iFC) between ICNs of interest was calculated by the use of Pearson’s correlation between-networks’ time courses. (A) Intra-iFC in the left anterior insula within the SN (turquoise spatial map) was significantly correlated with severity of negative symptoms in patients (partial correlation, r = −0.978, p < 0.001). (B) Furthermore, intra-iFC in the left anterior insula within the SN was significantly correlated with the inter-iFC between SN and CEN in patients (turquoise arrow, partial correlation, r = −0.961, p = 0.002). (C) Finally, the inter-iFC between SN and CEN was significantly correlated with the severity of negative symptoms (purple arrow, partial correlation, r = 0.969, p < 0.001). All partial correlations were corrected for age, sex, total GM volume, and medication (CPZ). Spatial maps indicate the anterior/inferior-posterior/superior-posterior default mode network (a/ip/spDMN), left-ventral/right-ventral/dorsal central executive network (lv/rv/dCEN), and salience network (SN) (see also Tables 6– 8).