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. 2004 Feb 23;101(9):3236–3241. doi: 10.1073/pnas.0308280101

Fig. 2.

Fig. 2.

The D1 receptor is involved in the maintenance but not the induction of LTP (rat). The D1 receptor inhibitor SCH23390 had no significant effect on the LTP induced by a single train of tetanus. ○, Control; •, SCH23390 (2 μM). (B) SCH23390 (2 μM) blocked the late phase of LTP induced by repeated tetanus. SCH23390 was applied 20 min before the first tetanus and perfused for 50 min. ○, Control; •, SCH23390. (C) The D2 inhibitor sulpiride had no significant effect on the LTP induced by repeated train of tetanus. ○, Control; •, sulpiride (50 μM). (D) D1 receptor agonist facilitated the maintenance of LTP. Subthreshold tetanus (100 Hz, 0.5 s) induced a short synaptic potentiation (○). In the presence of 6-chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide (6-APB; 2 μM), a stable long-lasting LTP was induced (•). (E) The application of 6-APB alone (2 μM) had no effect on the baseline fEPSP. (F) Anisomycin blocked the LTP induced by five trains of tetanus. ○, Control; •, anisomycin (20 μM) applied 30 min before the tetanus and perfused for 90-100 min.