. Author manuscript; available in PMC: 2014 May 9.

Published in final edited form as: J Med Chem. 2013 Apr 18;56(9):3492–3506. doi: 10.1021/jm301769u

Table 1.

HDAC inhibition activities of 3-HP and 3-HPT^*

X	HDAC1 IC₅₀ (nM)	HDAC6 IC₅₀ (nM)	HDAC8 IC₅₀ (nM)

O	NI^†	NI	NI
S	NI	681 ± 110	3675 ± 1201

Activities determined by SAMDI analysis

^†

No significant Inhibition (below 20% Inhibition) at maximum tested concentration of 10 μM