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. 2004 Feb 20;101(9):3258–3263. doi: 10.1073/pnas.0308744101

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Copyright © 2004, The National Academy of Sciences

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Fig. 3. — Increasing serum leptin reduces bone mass. (A) Six-month-old SAP-Leptin mice are mildly hyperleptinemic (leptin, ng/ml) and display a low bone volume over tissue volume (BV/TV, %) compared to controls (n = 4; ^*, P < 0.05). (B) Schematic representation of the ApoE/Lep transgene. Northern blot analysis confirmed the expression of the transgene in liver. ApoE/Lep mice have no fat pads (n = 8; ^*, P < 0.01). (C and D) Compared to controls, ApoE/lep mice at 3 (C) and 6 (D) months of age displayed a reduced bone volume and a decreased BFR/BS (μm³/μm² per yr) despite a 200- to 300-fold increase in serum leptin level (ng/ml) (n = 8; ^*, P < 0.05).