Fig. 2.
Blockade of GluA2-containing AMPAR endocytosis prevents memory destabilization on retrieval. (A) Behavioral procedure. (B) Microinfusion of GluA23Y at 1 h before retrieval into the LA rendered the memory insensitive to the amnesic effect of anisomycin, whereas the control peptide GluA23A did not block this amnesic effect. (C) When vehicle was microinfused immediately after retrieval instead of anisomycin, GluA23Y (filled square) had no effect on either retrieval or PR-LTM compared with GluA23A (open square). Diffusion of the GluA23Y peptide (1.5 nmol) was confined within the LA when measured at 1 h after the microinjection (Fig. S3A), and cannula tip placement was confirmed for the experiments shown in B and C (Fig. S3B).