Fig. 5.

Hypothetical model of synaptic mechanisms involved in memory consolidation, retrieval, and reconsolidation. After learning, LA synaptic strength is persistently potentiated, first mostly by CP-AMPARs but later almost solely by CI-AMPARs. On memory retrieval, NMDAR activity induces CI-AMPAR endocytosis and subsequent CP-AMPAR insertion, causing an unstable state of synaptic potentiation. Blocking this NMDAR activity or CI-AMPAR endocytosis prevents memory lability, occluding subsequent effects of anisomycin. The newly inserted CP-AMPARs contribute to memory reconsolidation and update, but are in turn removed from synapses over the course of reconsolidation.