Fig. 7.

Inhibition of Notch signaling blocked the development of hydrocephalus. (A) The development of an enlarged lateral ventricle (LV) and third ventricle (3V) induced by Rnd3 deficiency was prevented by treatment with compound E (Comp E). (Scale bar: 1 mm.) (B) Aqueduct stenosis was not seen in the brains of newborn Rnd3^−/− mice after treatment with compound E. Ce, cerebellum; Aq, aqueduct. (Scale bar: 200 μm.) (C) Expression levels of Hes1 protein in the brain tissues of WT and Rnd3^−/− mice were decreased by treatment with compound E. (D) Quantified results from C. *P < 0.05 compared with DMSO-treated WT mice.